Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. Dengue seroprevalence and risk factors for past and recent viral. During 20092010, a locally transmitted dengue outbreak was identified in key west, fl, and isolated autochthonous cases were found farther north in fl. Realtime rtpcr assay for detection and serotype identification of dengue virus instructions for use package insert catalog no. Subsequently, the awareness of variable responses to the infection presenting. Dengue fever is common in tropical areas, so take extra precautions if you.
For example, the highest incidence of cases in venezuela in 20 400 per 100 000 inhabitants were reported in children 20. Molecular epidemiology suggests venezuela as the origin of the dengue outbreak in madeira, portugal in 2012 20 april 2015 clinical microbiology and infection 117. Benjamin rush, a physician and signatory of the us declaration of independence, described a disease resembling dengue fever in philadelphia during 1780. Molecular epidemiology suggests venezuela as the origin of the dengue outbreak in madeira, portugal in 2012 20. Dengue virus is one of the most widespread mosquitoborne viruses worldwide, with an estimated annual infection rate around 390 million. During the summer of 20, a very localized outbreak of dengue occurred among residents of martin and st. Dengue fever df is the fastest emerging arboviral infection spread by aedes aegypti mosquitoes with major public health consequences for millions of people around the world, and in particular the southeast asia and asiapacific regions of the world health organization who. There were over 75,000 cases of dengue in venezuela in 20, compared to 46,708 in 2012. Uncertainty in burden estimates, however, challenges policy makers ability to set priorities, allocate resources, and plan for interventions. A study on viral transmission, risk factors and clinical disease. A risk to anyone traveling to a tropical or subtropical region of the world where dengue virus is found. In december 20, the first locally transmitted case of chikungunya in the americas was detected in saint martin. Estimating dengue incidence and hospitalization in malaysia. There are two peak seasons for dengue transmission in sri lanka.
The most affected areas include colombo, galle, kalutara, kandy, ratnapura, and gampaha. Epidemiology and disease burden of pediatric dengue in venezuela. Dengue has been historically present in the continental united states us, in the state of hawaii, and in the us insular territories in the caribbean and the pacific. Health experts have known about dengue fever for more than 200 years. Author summary dengue is a mosquitoborne viral disease of global impact. Today, dengue is regarded as the most prevalent and rapidly spreading mosquitoborne viral disease of human beings. According to economists interviewed by the new york times, the situation is the worst economic crisis. Dengues breaking public health records in venezuela. Dengue virus igm serotyping by elisa with recombinant mutant.
In this report, the first in a series on dengue, we explore the estimations of disease and economic burdens of dengue. The increase in frequency and magnitude of recent epidemics. Importantly, the past decade has also seen an upsurge in research on dengue virology, pathogenesis, and immunology and in development of antivirals, vaccines, and new vectorcontrol strategies that can positively impact dengue. Knowledge, attitudes, and preventive practices regarding dengue. Each year, an estimated 390 million people are infected. Risk of dengue exists throughout the country and transmission occurs yearround. Clinical and epidemiologic characteristics associated with dengue during and outside the 2016 outbreak identified in health facilitybased surveillance in ouagadougou, burkina faso. The origins of dengue and chikungunya viruses in ecuador. Impacting the health care crisis in venezuela, health care professionals are emigrating. In addition, there is an increased possibility of severe dengue cases due to cocirculation of. Epidemiology of dengue in latin america journal of the.
Dengvaxia zulassungempfehlung fur denguelebendimpfstoff. Emerg infect dis 2019 published online jun 10 emerg infect dis 2019 published online jun 10 view at emerg infect dis. The number of reported dengue fever infection cases in venezuela. It was the first sustained transmission of dengue in the european union since the 1920s. Recent cases of dengue have been reported from sri lanka. Complicacion fiebre hemorragica dengue forma mas severa del virus del dengue. Dengue case rates per 100 000 population, venezuela, 1980 20, all ages. A study on viral transmission, risk factors and clinical. Lucia martinique dominica antigua mariegalante barbuda st. The recent state of health in venezuela has seen that from 1992 to 1993, there was a cholera epidemic in the orinoco delta and venezuela s political leaders were accused of racial profiling of their own indigenous people to deflect blame from the countrys institutions, thereby aggravating the epidemic. This elisa enables more accurate reporting of epidemiologic findings. Our results revealed at least two introductions of denv, in 2011 and late 20, that initially originated from venezuela andor colombia.
The dengue seroprevalence in urban areas over the same period was constant. The 20 2014 chikungunya outbreak represented the first recorded outbreak of the disease outside of tropical africa and asia. It is marked by hyperinflation, escalating starvation, disease, crime and mortality rates, resulting in massive emigration from the country. Using phylogeographic analysis and complete envelope sequences we have demonstrated that the. Molecular epidemiology of dengue virus type 3 in venezuela. Infection with any one of the four dengue virus serotypes can cause disease that ranges from a mild febrile illness through to haemorrhagic fever and. Due to interruptions of water supply and electricity, residents in venezuela have to store water in receptacles that maintain favourable breeding conditions for aedes mosquitoes. Pdf molecular epidemiology of dengue virus type 3 in. Ensodriven climate variability promotes periodic major outbreaks. Since chikungunya virus emerged in the caribbean region in late 20.
For example, the highest incidence of cases in venezuela in 20 400 per 100 000 inhabitants were reported in children dengue virus serotypes 1, 2 and 4 denv1, 2 and 4 have been cocirculating in venezuela for at least the past 10 years, causing minor or major outbreaks of dengue fever df and dhfdss. Here, we identified the factors influencing community dengue preventive practices in a hightransmission urban area in venezuela. Asymptomatic dengue virus infections, cambodia, 2012 20. Molecular epidemiology suggests venezuela as the origin of.
For invitro diagnostic use ivd performance characteristics have been determined. We developed an igmbased elisa that identifies the dengue virus serotype of recent infections. Dengue risk areas centers for disease control and prevention. Molecular epidemiology suggests venezuela as the origin of the dengue outbreak in madeira, portugal in 2012.
Shortly after the first case the disease began to spread rapidly throughout the caribbean region. In venezuela, dengue has emerged as one of the most important public health. Mission report dengue outbreak in madeira, portugal, 20 1 1 summary from 26 september 2012 to 3 march 20, the autonomous province of madeira, portugal, reported its first dengue outbreak dengue1 virus. Since 2017, the banking sector has seen 18,000 employees leave the country. Sep 14, 2014 today, dengue is regarded as the most prevalent and rapidly spreading mosquitoborne viral disease of human beings. More than half of the global population lives in areas with risk of dengue transmission.
Dengue transmission in venezuela has become perennial and a major public health problem. Aug 02, 2018 the dengue incident rate decreased at a mean rate of 2. From 26 september 2012 to 3 march 20, the autonomous province of madeira, portugal, reported its first dengue outbreak dengue1 virus. Research note virology molecular epidemiology suggests venezuela as the origin of the dengue outbreak in madeira, portugal in 2012 20 l. Spatial analysis of dengue seroprevalence and modeling of.
We described and quantified the spatial and temporal events after the introduction and propagation of chikungunya into an immunologically naive population from the urban northcentral region of venezuela during 2014. Pdf knowledge, attitudes, and preventive practices regarding. According to official data from the ministry of health, cases of dengue rose by 40% in 20 compared to 2012. Spatial dynamics of chikungunya virus, venezuela, 2014. A global strategy on dengue fever and dhf was developed in 1995 and its implementation was bolstered in 1999. Between september 20 and february 2014, a crosssectional study at the household level was carried out in maracay city, venezuela. The figure was based on results from venezuelan ministry of health. Nov 02, 2018 we acquired denv pcrconfirmed and, thereby, serotypeclassified serum samples that we divided into 2 groups. Paho february 6, 2015 the 20 2014 chikungunya outbreak represented the first recorded outbreak of the disease outside of tropical africa and asia.
Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. We performed phylogeographic analyses of dengue denv and chikungunya chikv virus genomes sampled from a surveillance site in ecuador in 20142015, along with genomes from the surrounding countries. Published data showed that dengue virus type 1 introduced from south america was the incriminated virus. Dengue is a febrile illness caused by any of the four dengue virus types denv1 to 4, genus flavivirus, family flaviviridae mainly transmitted by the mosquito aedes aegypti.
Epidemiology and disease burden of pediatric dengue in. The venezuelan case find, read and cite all the research you need on researchgate. In venezuela, dengue is endemic with the cocirculation of the 4. Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of climate. Dengue risk areas areas with no known dengue risk aruba curacao bonaire trinidad venezuela blanquilla island st. The dengue incident rate decreased at a mean rate of 2. Sudamerika 2 brasilien, 2 venezuela, 2 sowohl in panama als auch in kolumbien. Maarteen republic puerto rico us virgin islands saba st. Dengue virus igm serotyping by elisa with recombinant.
Dengue case fatality rate, %, venezuela, 20002011 by age group. Pdf molecular epidemiology suggests venezuela as the. Dengue is a mosquitoborne viral disease of global impact. An explosive epidemic occurred in madeira island portugal from october 2012 to february 20. Published data showed that dengue virus type 1 introduced from south america was the. Estimating dengue incidence and hospitalization in. University of groningen dengue in venezuela velasco, zoraida rug. During the 1990s, the mortality rate was 318 per 100,000 people for heart and heartrelated. We aim to determine the origin of the strain introduced to madeira by travellers returning to europe. Dengue is thought to have been present in the usa since the end of the 18th century, when dr. This disease used to be called breakbone fever because it sometimes causes severe joint and muscle pain that feels like bones are breaking. Molecular epidemiology suggests venezuela as the origin of the dengue outbreak in madeira, portugal in 2012 20 author links open overlay panel l. The recent state of health in venezuela has seen that from 1992 to 1993, there was a cholera epidemic in the orinoco delta and venezuelas political leaders were accused of racial profiling of their own indigenous people to deflect blame from the countrys institutions, thereby aggravating the epidemic.